TYPES OF PATHOGENS: VIRUSES
Viruses are the smallest of the pathogens, being approximately l/500th the size of bacteria. Because of their tiny size, they are visible only under an electron microscope and were therefore not identified until this century. By the 1960s, viruses were being effectively grown outside the body in tissue cultures.
At present, over 150 viruses are known to cause diseases in humans. The role of viruses in the development of various cancers and chronic diseases is still unclear. In fact, much remains to be learned about viruses, perhaps the most unusual of all the microorganisms that infect humans.
Essentially, a virus consists of a protein structure that contains either ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). It is incapable of carrying out the normal cell functions of respiration and metabolism. It cannot reproduce on its own and can exist only in a parasitic relationship with the cell it invades. In fact some scientists question whether viruses should be considered living organisms.
When viruses attach themselves to host cells, they inject their own RNA or DNA, causing the host cells to begin reproducing new viruses. Once they take control of a cell, these new viruses overrun it until, filled to capacity, the cell bursts, putting thousands of new viruses into circulation to begin the process of cell invasion and reproduction all over again.
Because viruses cannot reproduce outside living cells, they are especially difficult to culture in a laboratory, making detection and study of these organisms extremely time-consuming. Treatment of viral diseases is also difficult because many viruses can withstand heat, formaldehyde, and large doses of radiation with little effect on their structure. In addition, some viruses may have incubation periods (the length of time required to develop fully and therefore to cause symptoms in their hosts) that are measured in years rather than hours or days. Termed slow-acting viruses, these viruses infect the host and remain in a semidormant state for years, causing a slowly developing illness. HIV is the most recent deadly example of a slow-acting virus.
Drug treatment for viral infections is limited. Drugs powerful enough to kill viruses also kill the host cells, although some available drugs block stages in viral reproduction without damaging the host cells.
We have another form of virus protection within our own bodies. When exposed to certain viruses, the body begins to produce a protein substance known as interferon. Interferon does not destroy the invading microorganisms but sets up a protective mechanism to aid healthy cells in their struggle against the invaders. Although interferon research is promising, it should be noted that not all viruses stimulate interferon production.
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